Recently, ceramides, which are the major lipid constituent of the stratum corneum, have been used in the treatment of eczema. They are often one of the ingredients of modern moisturizers. These lipids were also successfully produced synthetically in the laboratory.
A randomized control trial in infants found that subjects with atopic dermatitis that were treated with emollients (eg, Eucerin, Cetaphil, Nutraderm) had significantly decreased requirements for topical steroids compared with a control group who were not treated with them. Emollients are best applied immediately after bathing when the skin is well hydrated.