Losartan Pot. 50 mg + Hydrochlorthiazide 12.5 mg
Angilos-H 50/12.5 (losartan potassium-hydrochlorothiazide), Angilos-H 100/12.5 (losartan potassiumhydrochlorothiazide) and Angilos-H 100/25 (losartan potassium-hydrochlorothiazide) tablets combine an angiotensin II receptor blocker acting on the AT 1 receptor subtype and a diuretic, hydrochlorothiazide.
Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol-5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt. Its empirical formula is C22H22ClKN6O, and its structural formula is:
Losartan potassium is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone.
Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.
Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H8ClN3O4S2 and its structural formula is:
Hydrochlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 297.74, which is slightly soluble in water, but freely soluble in sodium hydroxide solution.
Angilos-H is available for oral administration in three tablet combinations of losartan and hydrochlorothiazide. Angilos-H 50/12.5 contains 50 mg of losartan potassium and 12.5 mg of hydrochlorothiazide. Angilos-H 100/12.5 contains 100 mg of losartan potassium and 12.5 mg of hydrochlorothiazide. Angilos-H 100/25 contains 100 mg of losartan potassium and 25 mg of hydrochlorothiazide. Inactive ingredients are microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide. Angilos-H 50/12.5 and Angilos-H 100/25 also contain D&C yellow No. 10 aluminum lake. Angilos-H 50/12.5, Angilos-H 100/12.5, and Angilos-H 100/25 may also contain carnauba wax.
Angilos-H 50/12.5 contains 4.24 mg (0.108 mEq) of potassium, Angilos-H 100/12.5 contains 8.48 mg (0.216 mEq) of potassium, and Angilos-H 100/25 contains 8.48 mg (0.216 mEq) of potassium.